Author, Institution: Povilas Kavaliauskas, Kaunas University of Technology
Science area, field of science: Natural Sciences, Chemistry, N003
Research supervisor: Prof. Dr. Hab. Vytautas Mickevičius (Kaunas University of Technology, Natural Sciences, Chemistry, N003)
Research consultant: Assoc. Prof. Dr. Birutė Grybaitė (Kaunas University of Technology, Natural Sciences, Chemistry, N003)
Dissertation Defence Board of Chemistry Science Field:
Prof. Dr. Eglė Arbačiauskienė (Kaunas University of Technology, Natural Sciences, Chemistry, N003) – chairperson
Chief Researcher Dr. Linas Labanauskas (State Research Institute Center for Physical Sciences and Technology, Natural Sciences, Chemistry, N003)
Prof. Dr. Vytas Martynaitis (Kaunas University of Technology, Natural Sciences, Chemistry, N003)
Senior Researcher Dr. Kasparas Rakštys (Kaunas University of Technology, Natural Sciences, Chemistry, N003)
Assoc. Prof. Dr. Jolanta Rousseau (Artois University, France, Technological Sciences, Chemical Engineering, T005)
Dissertation defence meeting will be at Rectorate Hall of Kaunas University of Technology (K. Donelaičio 73-402, Kaunas)
The doctoral dissertation is available at the library of Kaunas University of Technology (Gedimino 50, Kaunas) and on the internet: P. Kavaliauskas el. dissertation.pdf
© P. Kavaliauskas, 2026 “The text of the thesis may not be copied, distributed, published, made public, including by making it publicly available on computer networks (Internet), reproduced in any form or by any means, including, but not limited to, electronic, mechanical or other means. Pursuant to Article 25(1) of the Law on Copyright and Related Rights of the Republic of Lithuania, a person with a disability who has difficulties in reading a document of a thesis published on the Internet, and insofar as this is justified by a particular disability, shall request that the document be made available in an alternative form by e-mail to doktorantura@ktu.lt.”
Annotation: This doctoral dissertation focuses on the design, synthesis, and biological characterization of novel N-substituted N-carboxyethyl-β-alanine derivatives bearing phenolic moieties. A diverse library of β-amino acid derivatives containing 2-, 3-, and 4-hydroxyphenyl fragments was developed using aza-Michael addition, hydrazone formation, heterocyclic synthesis, and related synthetic strategies. The synthesized compounds were characterized using nuclear magnetic resonance spectroscopy, high-resolution mass spectrometry, and other analytical methods. Biological evaluation demonstrated that several synthesized compounds exhibited promising antimicrobial activity against multidrug-resistant Gram-positive bacterial pathogens, as well as antifungal activity. In addition, selected derivatives showed cytotoxic effects against cancer cell lines and possessed antioxidant properties. Structure–activity relationship analysis revealed that the position of the phenolic moiety and the nature of N-substitution significantly influenced the biological activity of the compounds. The results of this dissertation expand current knowledge on the synthesis and functionalization of phenolic β-amino acid derivatives and highlight their potential application as novel antimicrobial and anticancer candidates.