The topic of this project corresponds to the KTU priority research areas: Technologies for a Sustainable Future: Applied and Medicinal Chemistry, and Vytautas Magnus University research areas: Biosystems Engineering.
The progress of pharmaceutical industry depends on new biologically active substances availability. Despite the widespread interest in pyrazole chemistry, many unresolved challenges remain, such as the synthesis and biotesting of polycyclic pyrazole derivatives. Based on this, the concept of current project was formulated: the development of novel bipyrazole derivatives synthetic procedures and their applicability in anticancer therapy.
It is expected to achieve a significant progress in the application of readily available hydroxypyrazole as a universal precursor of polycyclic substances. For the elaboration of chemical transformations, the modern organic synthesis methods covering Green chemistry principles (catalysis, atom economy, safer reaction conditions, safer solvents, increase energy efficiency) will be developed. In the framework of this project, the effect of synthesized bipyrazole-containing derivatives on cell viability (1 non cancer and 2 cancer cell cultures) utilised in combination with chemotherapeutical drugs will be investigated.
Project funding:
KTU Research and Innovation Fund
Project results:
The results of these new compounds anti-cancer activities biotesting are also important for global fundamental research related to the application of artificial intelligence in the development of anticancer drugs. Obtained results are also significant in the development of low molecular mass compound libraries as a source for structure-activity relationship investigation.
Period of project implementation: 2022-04-01 - 2022-12-31
Project partners: Vytautas Magnus University
