Indole is one of the most common alkaloids in nature – it is produced in large quantities by bacteria and plants. Many of indole alkaloids have physiological activity and some of them are used in medicine. From the broad class of indole alkaloids, 3,3′-bisindolylmethanes (BIM) with a relatively simple structure are exclusively interesting compounds. A lot of these compounds are used in medicine and pharmacology because of their properties. These compounds have also been shown to have biological activity – antioxidant, cytotoxic, antibacterial activity. Several studies have shown that synthetic BIMs can be adapted to combat Alzheimer’s, Huntigton’s, amyloidosis, and even Parkinson’s disease. This project is aimed for the synthesis of new variuosly bisindole and its isostere derivatives. These compounds are expected to have excellent neuroprotective properties against Parkinson’s disease.
Project funding:
Project is funded by EU Structural Funds according to the 2014–2020 Operational Programme for the European Union Funds’ Investments priority “Development of scientific competence of researchers, other researchers, students through practical scientific activities” under Measure No. 09.3.3-LMT-K-712.
Project results:
During the project, a new study on the synthesis of bisindole and its isosteric derivatives was performed. In the first stage, a detailed literature analysis was performed. The Suzuki cross-coupling reaction yielded 5-phenyl substituted indole derivative. In the second stage, the synthesis of bisindole derivatives using condensation reactions and the optimization of reaction conditions were performed. In the third step, the investigation of the synthesis of carbazole derivatives from synthesized bis (1H-indoles) was performed.
Period of project implementation: 2020-11-03 - 2021-04-30
Project coordinator: Kaunas University of Technology
