The idea of the project is the synthesis of new chalcone and flavone derivatives containing a 1-phenylpyrazole moiety using modern organic chemistry methods. Synthesized condensed pyrazole molecules could find practical application in the fields of medicinal chemistry.
Flavone derivatives containing a phenylpyrazole moiety have various activities: anticancer [Chem Heterocycl Comp, 2016, 52, 1, 15], antibacterial [Chem Heterocycl Comp, 2016, 52, 3, 172], anti-oxidant [RSC Advances, 2015, 5, 42, 33562], antidiabetic [Arabian J Chem, 2017, 10, S3895] and antifungal [Med Chem Res, 2016, 25, 501]. Chalcones containing a phenylpyrazole moiety, meanwhile, are in demand as biologically active molecules not only in the pharmaceutical industry but also as potential biologically active preparations for use in agriculture [J Chilean Chem Soc, 2018, 63, 2, 3983; J Plant Protection Res, 2012, 52, 1, 146].
Although many research groups work in the field of pyrazole chemistry, the direction of research on pyrazole derivatives with chalcone and flavone structures is promising and has not yet been extensively investigated.
Project funding:
Project is funded by EU Structural Funds according to the 2014–2020 Operational Programme for the European Union Funds’ Investments priority “Development of scientific competence of researchers, other researchers, students through practical scientific activities” under Measure No. 09.3.3-LMT-K-712.
Project results:
From the initial alkylated pyrazole molecules, new, functionalized chalcone and flavone derivatives containing a pyrazole moiety were synthesized via a Vilsmeier-Haack reaction mechanism and condensation reactions of pyrazole carbaldehydes using various aromatic acetyl alcohols. Also perform a detailed structural analysis of the obtained compounds.
Period of project implementation: 2021-09-01 - 2022-03-31
Project coordinator: Kaunas University of Technology
