The aim of this interdisciplinary project, which combines the researchers of the organic synthesis and impact researchers of various chemical compounds on bacteria, is to synthesize new biologically active organic compounds that would help to avoid the problem of multidrug resistant bacteria. Multidrug resistance is the bacterial resistance to antibiotics, related with the most frequent nonselective efflux of substrates from the cell. Although the antibiotic resistance of clinically relevant bacteria is increasing, the number of new antibacterial agents for treatment is decreasing. Pharmaceutical companies are unlikely to develop and introduce new compounds into medical practice if they remain effective for a short period of time, precisely because of the high resistance of bacteria to antibiotics. One way of solving this problem is the synthesis of new biologically active compounds that inhibit the activity of antibiotic efflux pumps in bacteria. The synthesis and the use of novel non-toxic and biologically stable compounds for bacterial treatment is relevant to the theoretical and practical use in medicine.
Project funding:
KTU R&D&I Fund
Project results:
New potential organic materials for multidrug resistance pumps (DVA) have been synthesized. The effect of new DVA pump suppressors on Gram-negative bacterial viability was assessed – determination of minimum inhibitory concentration, reproduction kinetics, bacterial membrane integrity studies. The influence of synthesized potential inhibitors of DVA pumps on the antibacterial and bacteriostatic effects of different classes of antibiotics on Gram-negative bacteria was evaluated.
Period of project implementation: 2019-04-01 - 2019-12-31
Project partners: Vytautas Magnus University
