The project will develop and investigate new oxygen-sensitive organic materials exhibiting long-lived emission that will be used as biomarkers for brain imaging. The overall goal of project is to design, synthesize and to evaluate the suitability of organic compounds exhibiting long-lived emission in solutions as biomarkers in cells and tissues. These compounds change their luminescence colour and intensity upon variation of oxygen concentration in the ambience. The oxygenation level is a fundamental indicator for physiological condition in brains, where multiphoton microscopy investigation is the mainstream technique that offers millimeter penetration depth and sub-micrometer spatial resolution.
Project funding:
Interngovernmental programme administrated by Research Council of Lithuania: Lithuania–Latvia–China (Taiwan)
Project results:
In this collaboration, the Lithuanian partners are strong in organic material fabrication/characterization, the Latvian partners have expertise on molecule design/ synthesis, and the Taiwanese partners have extensive experience on multiphoton brain imaging. We will work together to explore and optimize the multiphoton emission efficiency of oxygen-sensitive organic materials, as well as to apply the technique toward brain oxygenation mapping.
Period of project implementation: 2024-01-02 - 2026-12-31
Project coordinator: Kaunas University of Technology
Project partners: Latvian Institute of Organic Synthesis, National University of Taiwan
