Assessment and monitoring of intracranial pressure (ICP) changes are important in the management of cerebral pathologies. ICP increase and decrease both also correlate with optic neuropathies, the former because of papilledema and the latter related to glaucoma. While the relationship between ICP elevation and papilledema is well established, the relationship between low ICP and glaucoma is still poorly understood. So far, ICP monitoring is performed invasively, but this entails risks including infection, spurring the study of non-invasive alternatives. While none of current methods in use can fully replace invasive techniques, certain measures show great potential for specific applications. Treatment of normal tension glaucoma as a two pressure disease needs periodic intracranial dynamic monitoring sessions for evaluation of treatment effectiveness and for needed corrections of treatment methodology. Project aim is to be able to monitor the “missing link” of intracranial dynamics of patients with normal tension glaucoma according to circadian rhythm: in the morning, during lunch and in the evening. The opportunity to monitor high temporal resolution ICP waves non-invasively for patients with normal tension glaucoma will be implemented for the first time by using novel non-invasive intracranial pressure waves realtime monitoring system invented by KTU team in 2022 (patent applications are registered in the EU and USA).
Project funding:
Projects funded by the Research Council of Lithuania (RCL), Projects carried out by researchers’ teams
Project results:
The development of a high temporal resolution non-invasive intracranial pressure wave monitoring system and a clinical study of normal pressure glaucoma patients will provide a package of evidence-based recommendations to facilitate the integration of normal pressure glaucoma treatment into the health system. It is planned to prepare one international patent application, publish two Q1 quartile WoS articles, and present the results in one conference.
Period of project implementation: 2023-05-26 - 2025-03-31
Project coordinator: Lithuanian University of Health Sciences
Project partners: Kaunas University of Technology
