The growing threat of antimicrobial resistance (AMR) highlights the urgent need for novel therapeutic agents capable of overcoming resistant pathogens. This project proposes the development of hybrid organic compounds that combine antimicrobial and antioxidant properties, targeting both microbial pathogens and the oxidative stress associated with infections. The research focuses on synthesizing a series of novel pyridine derivatives bearing N-containing moieties such as 1,2,4-triazole, 5-oxopyrrolidine, oxoindole, hydrazone, etc. The project includes the design, synthesis, and structural optimization of these compounds, employing various substituents to enhance activity. The synthesized compounds will undergo biological activity evaluation in silico and screening in vivo against a broad panel of bacterial and fungal strains, as well as in antioxidant assays, to identify lead structures for further development. It aligns with global health priorities set by World Health Organisation (WHO) by addressing AMR through new chemistry-based solutions.
Project funding:
Research Council of Lithuania, Projects carried out by researchers’ teams
Project results:
This research aims to contribute to the worldwide search for novel antimicrobial agents through innovative molecular design, contributing to the discovery of effective, dual-acting therapeutic candidates.
Period of project implementation: 2025-11-03 - 2028-10-31
Project coordinator: Kaunas University of Technology
