Real-Time Non-Invasive Monitoring of Cerebral Autoregulation During Cardiopulmonary Bypass: Development and Asssessment of Archimedes 02 and fNIRS Technologies. Cardiopulmonary bypass (CPB) is used in over 2 million heart surgeries annually, but is linked to highrates (33%–83%) of postoperative cognitive dysfunction (POCD) and delirium. These complications lead to long-term impairment in up to40% of patients and generate significant healthcare costs across the EU and US. A major cause is impaired cerebral autoregulation (CA),which can lead to brain injury during CPB if not detected in time. Current CA monitoring methods are slow and lack the sensitivity required for timely intervention—critical, as neuronal death occurs within minutes of perfusion failure. Our project addresses this unmet clinical need by developing and validating a real-time, non-invasive multimodal CA(t) monitoring system. We propose to integrate two advanced technologies: Archimedes 02 – a patented system for continuous monitoring of intracranial volumetric waves; Functional Near-Infrared Spectroscopy (fNIRS) – high-resolution monitoring of cerebral oxygenation. Both systems will assess CA transient responses triggered by rectangular modulation of arterial blood flow via the heart-lung machine. This will be the first clinical use of both technologies in this context. A prospective intraoperative pilot study will be conducted to evaluate and compare the two systems. The project will produce anassessed, multimodal CA monitoring technology, enabling precise detection of ischemia and hyperemia events and supporting personalized brain perfusion management during CPB.
Project funding:
Research Council of Lithuania, Projects carried out by researchers’ teams
Period of project implementation: 2025-11-03 - 2027-10-31
Project coordinator: Kaunas University of Technology
Project partners: Lithuanian University of Health Sciences
