Hydrogels are regarded as hydrophilic polymer networks having very high water absorption ability. Hydrogels can convert one form of energy into other form. Due to their chemical and physical properties, biocompatibility and pH responsive properties, hydrogels can be used as important tool in diagnostics and sensors. In this research proposal we are focusing on the use of hydrogels in glucose sensing application, enzyme biomolecules can be entrapped in hydrogels matrix. Glucose enzyme biosensors have been utilized in different type of fields such as diagnosis, beverage industry, bioprocess and environmental problem. The stability and functionality can be increased by loading the nanoparticles into the hydrogels matrix. There is synergistic action between hydrogels and nanoparticle for glucose sensing application. The immobilization of the enzyme into hydrogel matrix can be favored by porosity of hydrogels structure, which can further help in glucose oxidation. Nanoparticles can promote the decomposition reaction of hydrogen peroxide throughout the enzymatic reaction. All these transfer charges will be measured electrochemically by using a series of multifunctional robust three dimensional conducting hydrogels.
Project funding:
This research project is funded by the European Social Fund according to the 2014–2020 Operational Programme for the European Union Funds’ Investments, under measure’s No. 09.3.3-LMT-K-712 activity “Promotion of postdoctoral fellowships studies”.
Project results:
Multifunctional robust three dimensional hydrogel composites for glucose oxidase immobilization and biosensing will be exploited for the first time. Glucose sensor with synergic effect of polymer hydrogels and nanoparticles will be obtained. The hydrogel composites will show good potential in glucose sensing due to superior physico-mechanical properties and facile conjugation responses. Glucose biosensor with excellent sensitivity, selectivity and stability for long-term will be developed.
Publication:
Sourbh Thakura, Jyoti Chaudharyb, Vinod Kumarc, Vijay Kumar Thakurd, Progress in pectin based hydrogels for water purification: Trends and Challenges, Journal of Environmental Management 238 (2019) 210–223,
https://doi.org/10.1016/j.jenvman.2019.03.002
Period of project implementation: 2017-11-28 - 2019-11-27
Project coordinator: Kaunas University of Technology
