Author, Institution: Viktorija Savickienė, Kaunas University of Technology
Science area, field of science: Natural Sciences, Chemistry, N003
Research supervisor: Prof. Dr. Eglė Arbačiauskienė (Kaunas University of Technology, Natural Sciences, Chemistry, N003)
Research consultant: Prof. Dr. Hab. Algirdas Šačkus (Kaunas University of Technology, Natural Sciences, Chemistry, N003)
Dissertation Defence Board of Chemistry Science Field:
Senior Researcher Dr. Marytė Daškevičienė (Kaunas University of Technology, Natural Sciences, Chemistry, N003) – chairperson
Prof. Dr. Hab. Linas Labanauskas (State Research Institute Center for Physical Sciences and Technology, Natural Sciences, Chemistry, N003)
Prof. Dr. Tadas Malinauskas (Kaunas University of Technology, Natural Sciences, Chemistry, N003)
Prof. Dr. Vytas Martynaitis (Kaunas University of Technology, Natural Sciences, Chemistry, N003)
Dr. Asta Žukauskaitė (Palacky University Olomouc, Czech Republic, Natural Sciences, Chemistry, N 003)
Dissertation defence meeting will be at Rectorate Hall of Kaunas University of Technology (K. Donelaičio 73-402, Kaunas)
The doctoral dissertation is available at the library of Kaunas University of Technology (Gedimino 50, Kaunas) and on the internet: V. Savickienė el. dissertation.pdf
© V. Savickienė, 2026 “The text of the thesis may not be copied, distributed, published, made public, including by making it publicly available on computer networks (Internet), reproduced in any form or by any means, including, but not limited to, electronic, mechanical or other means. Pursuant to Article 25(1) of the Law on Copyright and Related Rights of the Republic of Lithuania, a person with a disability who has difficulties in reading a document of a thesis published on the Internet, and insofar as this is justified by a particular disability, shall request that the document be made available in an alternative form by e-mail to doktorantura@ktu.lt.”
Annotation: In this work, multicomponent reactions were carried out using compounds with a pyrazole structure as starting components in order to synthesize new heterocyclic compounds. Although multicomponent reactions are widely used in the synthesis of heterocyclic compounds, the inclusion of pyrazole in such reactions has not been extensively studied. During the multicomponent reaction, 3-methoxy-1-phenyl-1H-pyrazole-4-carbaldehydes were reacted with hydrazine hydrate, malononitrile, ethyl 3-oxobutanoate and catalyzed by isonicotinic acid, 6-amino-4-(pyrazol-4-yl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles were obtained for the first time 6-Amino-4-(3-methoxy-1-phenyl-1H-pyrazol-4-yl)-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile was further various cyclohexanones, yielded 2,4,6,7,8,9-hexahydropyrazolo[4′,3′:5,6]pyrano[2,3-b]quinolin-5-amines containing one or two chiral centers. Hantzsch’s multicomponent synthesis of pyridines yielded 4-(pyrazol-4-yl)-1,4-dihydropyridines, which were further oxidized to form a pyridine ring. The multicomponent reaction of pyrazole-4-carbaldehyde, β-ketoesters and hydroxylamine hydrochloride yielded 4-[(pyrazol-4-yl)methylene]isoxazol-5(4H)-one derivatives for the first time. Pyrazole-boron complexes as analogues of BASHY complexes were obtained for the first time by reacting 1-phenyl-3-hydroxy-1H-pyrazole-4-carbaldehyde with various anthranilic and boronic acids in a multicomponent reaction. The photophysical properties of these compounds were studied in various solvents. The compounds can be further investigated as luminescent materials or probes.