Author, Institution: Urtė Šachlevičiūtė, Kaunas University of Technology
Science area, field of science: Natural Sciences, Chemistry, N003
Scientific Supervisors: Assoc. Prof. Dr. Neringa Kleizienė (Kaunas University of Technology, Natural Sciences, Chemistry, N003) (04 October 2021 – 31 August 2024);
dr. Greta Račkauskienė (Kaunas University of Technology, Natural Sciences, Chemistry, N003) (01 September 2020 – 03 October 2021)
Dissertation Defense Board of Chemistry Science Field:
Assoc. Prof. Dr. Vida Malinauskienė (Kaunas University of Technology, Natural Sciences, Chemistry, N003) – chairperson
Senior Researcher Dr. Virginija Dudutienė (Vilnius University, Natural Sciences, Chemistry, N003)
Prof. Dr. Vytautas Getautis (Kaunas University of Technology, Natural Sciences, Chemistry, N003)
Assoc. Prof. Dr. Birutė Grybaitė (Kaunas University of Technology, Natural Sciences, Chemistry, N003)
Assoc. Prof. Dr. Lucie Plihalova (Palacky University Olomouc, Czech Republic, Natural Sciences, Chemistry, N003)
Dissertation defense meeting will be at Rectorate Hall of Kaunas University of Technology (K. Donelaičio 73-402, Kaunas)
The doctoral dissertation is available at the library of Kaunas University of Technology (Gedimino 50, Kaunas) and on the internet: U. Šachlevičiūtė el. dissertation (PDF)
Annotation: Chemistry of heterocyclic compounds is a rapidly developing field of organic chemistry. Nitrogen heterocycles attract considerable attention because they are the key structural elements of various natural products, vitamins, pharmaceuticals, agrochemicals, and other organic functional materials. Nitrogen-containing heterocyclic molecules are particularly useful in medicinal chemistry, as they possess a broad spectrum of pharmacological activities. Novel azetidine and pyrrolo[2,1-a]isoquinoline compounds have been synthesized and investigated in this work. In the first part, novel potentially biologically active 3-substituted azetidine derivatives were obtained, including 3-aryl-azetidin-3-yl acetic acid methyl ester derivatives which were investigated for their neuroprotective activity by in vitro assays. Multi-step synthetic pathways have also been developed for the synthesis of azetidin-3-yl derivatives with the fused bicyclic moieties starting from 1-Boc-azetidine-3-carboxylic acid. In the second part, the research work of pyrrolo[2,1-a]isoquinolines is discused. A novel one-pot synthesis method has been applied for the synthesis of functionalized 5,6-dihydropyrrolo[2,1-a]isoquinolines which were investigated for their anticancer activity. Furthermore, a novel synthetic route to the pyrrolo[2,1-a]isoquinoline ring system has been developed. This methodology has been further applied to the total synthesis of lamellarin G trimethyl ether.
September 27 d. 09:00
Rectorate Hall at Kaunas University of Technology (K. Donelaičio 73-402, Kaunas)
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