T. Juknius “Applications of diamond like carbon and silver nanocomposites for preparation of external use pharmaceuticals” doctoral dissertation defence

Thesis Defense

Author, Institution: Tadas Juknius, Kaunas University of Technology

Science area, field of science: Technological Sciences, Materials Engineering , T008

Scientific Advisor: Prof. Dr. Habil. Sigitas Tamulevičius (Kaunas University of Technology, Technological Sciences, Materials Engineering, T008)

Dissertation Defence Board of Materials Engineering Science Field:|
Prof. Habil. Dr. Arvaidas Galdikas (Kaunas University of Technology, Technological Sciences, Materials Engineering, T008) – chairperson
Prof. Habil. Dr. Yuri Dekhtyar (Riga Technical University, Latvia, Natural Sciences, Physics, N002)
Prof. Habil. Dr. Valdimaras Janulis (Lithuanian University of Health Sciences, Medicine and Health Sciences, Pharmacy, M003)
Prof. Dr. Daiva Mikučionienė (Kaunas University of Technology, Technological Sciences, Materials Engineering, T008)
Assoc. Prof. Dr. Ieva Plikusienė (Vilnius University, Technological Sciences, Materials Engineering, T008)

The doctoral dissertation is available on the internet at the library of Kaunas University of Technology (K. Donelaičio g. 20, Kaunas).

Annotation:

The wounds treatment due to antibiotic-resistant S. aureus bacteria, in hospitals becoming more difficult, mixtures of different antibiotics are used, but treatment is not always successful. The healing properties of silver have long been known, and its various forms are used in medicine.
This dissertation presents a unique patented patch applying a diamond like carbon coating with silver nanoparticles (DLC: Ag), developed by researchers at the Institute of Materials Sciences at KTU. The chemical composition, silver concentration, and the particle size distribution correlation were investigated. The oxygen plasma etching effect at different time intervals of DTAD: Ag surface was investigated, antimicrobial effect and the release of silver ions into the aqueous medium properties has been determined. The antimicrobial effect of different concentrations of silver ion-saturated solutions on different strains of S. sureus bacteria was also investigated. Based on all study data, one DLC: Ag coating was elected and used to create the patch.
The created uniquely designed patch with DLC: Ag which was sputtered on nylon fabric by unbalanced reactive magnetron, was tested under laboratory conditions, followed by review clinical trials with laboratory animals. A 5-layer patch with DLC:Ag coating inside contained faster and longer antimicrobial effect due to the existing silver ion accumulation layer. The structure of the patch prevented it from adhering to the tissues, a sterile medium was created above the wound – the methicillin-resistant strain of S. aureus was destroyed on the third day of treatment, and the wounds healed 40% faster without side effects. 

February 3 d. 14:00

Dissertation Defense Hall at Kaunas University of Technology (K. Donelaičio g. 73-403, Kaunas)

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