K. Dzedulionytė “Synthesis and Biological Activity Evaluation of Novel Pyrazolo[1,5-a][1,4]diazepin-4-ones and 3,4-Diaryl-1H-pyrazole-5-carboxylates” doctoral dissertation defense

Author, Institution: Karolina Dzedulionytė, Kaunas University of Technology

Science area, field of science: Natural Sciences, Chemistry, N003

Scientific Supervisor: Assoc. Prof. Dr. Eglė Arbačiauskienė (Kaunas University of Technology, Natural Sciences, Chemistry, N003)

Scientific Advisor: Dr. Asta Žukauskaitė (Palacky University Olomouc, Czech Republic, Natural Sciences, Chemistry, N003)

Dissertation Defense Board of Chemistry Science Field:
Prof. Dr. Vytas Martynaitis (Kaunas University of Technology, Natural Sciences, Chemistry, N003) – chairperson
Senior Researcher Dr. Virginija Dudutienė (Vilnius University, Natural Sciences, Chemistry, N003)
Senior Researcher Dr. Artiom Magomedov (Kaunas University of Technology, Natural Sciences, Chemistry, N003)
Prof. Dr. Hab. Vytautas Mickevičius (Kaunas University of Technology, Natural Sciences, Chemistry, N003)
Assoc. Prof. Dr. Lucie Plihalova (Palacky University Olomouc, Czech Republic, Natural Sciences, Chemistry, N003)

Dissertation defense meeting will be at Rectorate Hall of Kaunas University of Technology (K. Donelaičio 73-402, Kaunas)

The doctoral dissertation is available at the library of Kaunas University of Technology (Gedimino 50, Kaunas).

Annotation: Pyrazoles are common scaffolds in organic and medicinal chemistry, often used as an outset for the preparation of more complex molecular systems with relevance in the pharmaceutical field. These heterocycles have marked their importance amongst academia and the pharmaceutical industry, where pyrazole moiety-containing molecules are used as approved drugs or currently are under investigation for expanded applications. This doctoral thesis covers the synthesis and investigation of novel pyrazole-based small molecular weight compounds. The research was mainly focused on two directions – the creation of new fused pyrazole-diazepinone systems with potential biological activity as well as the synthesis of nature-inspired lamellarin O analogues bearing a pyrazole core with the aim to improve anticancer activity of the natural compound.