„Investigation of the complex electronic system dedicated for the human non-invasive absolute intracranial pressure measurement“ Doctoral Thesis

Author, institution: Laimonas Bartušis, Kaunas University of Technology

Science area, field: Technological Sciences, Electrical and Electronic Engineering

The Doctoral Dissertation is available at the library of Kaunas University of Technology (K. Donelaičio St. 20, Kaunas).

Scientific Supervisor: Prof. Dr. Arminas RAGAUSKAS (Kaunas University of Technology, Technological Sciences, Electrical and Electronics Engineering – 01T).

Dissertation defence board of Electrical and Electronic Engineering Science Field

Prof. Dr. Algimantas VALINEVIČIUS (Kaunas University of Technology, Technological Sciences, Electrical and Electronics Engineering – 01T) – Chairman;
Prof. Dr. Habil. Arūnas LUKOŠEVIČIUS (Kaunas University of Technology, Technological Sciences, Electrical and Electronics Engineering– 01T);
Prof. Dr. Renaldas RAIŠUTIS (Kaunas University of Technology, Technological Sciences, Electrical and Electronics Engineering – 01T);
Prof. Dr. Habil. Edmundas ŠIRVINSKAS (Lithuanian University of Health Sciences, Biomedical Sciences, Medicine – 07B);
Prof. Dr. Antanas VAITKUS (Lithuanian University of Health Sciences, Biomedical Sciences, Medicine – 07B).

Annotation:

Intracranial pressure (ICP) is a cerebrospinal fluid pressure inside the skull or spinal canal. Absolute ICP can only be measured by using the invasive methods in worldwide clinical practice. The scientific-technological problem that is solved in this work is as follows: in which way it is possible to measure the non-invasively and without the assistance of a highly qualified specialist the absolute value of ICP with the accuracy, precision and duration required for the clinical practice? The work hypothesis follows from the formulation of the problem: it is possible to measure the absolute value of ICP non-invasively and without the assistance of a highly qualified specialist with accuracy, precision and duration required for the clinical practice by using the patented non-invasive ICP measurement method proposed by prof. A. Ragauskas and automating location of the intracranial (IOA) and extracranial (EOA) segments of the ophthalmic artery (OA) required for the ICP measurement. The work hypothesis is proved by means of the statistically reliable non-invasive ICP measurements of neurologic, severe traumatic brain injured, glaucoma patients and healthy volunteers. The location algorithm of internal carotid artery and IOA and EOA segments of the OA was created and revealed in this work, which automatically controls the spatial position and orientation of ultrasonic transducer on the closed eyelid. Depths of IOA and EOA segments needed for the ICP measurement and the duration of the segments location were determined experimentally by using the developed location algorithm.