Author, Institution: Inesa Zagorskytė, Kaunas University of Technology
Science area, field of science: Natural Sciences, Chemistry, N003
Research supervisor: Prof. Dr. Eglė Arbačiauskienė (Kaunas University of Technology, Natural Sciences, Chemistry, N003)
Research consultant: Prof. Dr. Hab. Algirdas Šačkus (Kaunas University of Technology, Natural Sciences, Chemistry, N003)
Dissertation Defence Board of Chemistry Science Field:
Prof. Dr. Vytautas Getautis (Kaunas University of Technology, Natural Sciences, Chemistry, N003) – chairperson
Senior Researcher Dr. Virginija Dudutienė (Vilnius University, Natural Sciences, Chemistry, N003)
Prof. Dr. Tadas Malinauskas (Kaunas University of Technology, Natural Sciences, Chemistry, N003)
Prof. Dr. Vytas Martynaitis (Kaunas University of Technology, Natural Sciences, Chemistry, N003)
Prof. Dr. Kamil Musilek (University of Hradec Králové, Czech Republic, Natural Sciences, Chemistry, N 003)
Dissertation defence meeting will be at Rectorate Hall of Kaunas University of Technology (K. Donelaičio 73-402, Kaunas)
The doctoral dissertation is available at the library of Kaunas University of Technology (Gedimino 50, Kaunas) and on the internet: I. Zagorskytė el. dissertation.pdf
© Inesa Zagorskytė, 2026 “The text of the thesis may not be copied, distributed, published, made public, including by making it publicly available on computer networks (Internet), reproduced in any form or by any means, including, but not limited to, electronic, mechanical or other means. Pursuant to Article 25(1) of the Law on Copyright and Related Rights of the Republic of Lithuania, a person with a disability who has difficulties in reading a document of a thesis published on the Internet, and insofar as this is justified by a particular disability, shall request that the document be made available in an alternative form by e-mail to doktorantura@ktu.lt.”
Annotation: Glycerol-1,2-carbonate is a green reagent derived from glycerol – a major byproduct of biodiesel industry. In this work, tosylated glycerol-1,2-carbonate was used for the alkylation of ethyl 1H-pyrazole-5(3)-carboxylates, methyl 1(2)H-indazole-3-carboxylate, methyl 1H-pyrrole-2-carboxylate and different 1H-indole-2-carboxylates. 2-Oxo-1,3-dioxolane ring transformations of various 1-[(2-oxo-1,3-dioxolan-4-yl)methyl]-1H-pyrazoles were explored by reacting with amines, thiols and hydrides. Fused pyrazole, indazole, indole, and pyrrole oxazines were obtained through base-induced decarboxylation of N-glycerylated compounds having (2-oxo-1,3-dioxolan-4-yl)methyl adjacent to the carboxylate group, along with ester hydrolysis, and followed by intramolecular ester condensation. Stuctural diversity of 1H-[1,4]oxazino[4,3-a]indol-1-ones were expanded through O-, N-, S-alkylation of 3-hydroxymethyl group, while 10-(hetero)arylated derivatives were obtained through halogenation and Pd-catalysed coupling or formylation and condensation sequences. Photophysical properties of 10-(hetero)arylated-1H-[1,4]oxazino[4,3-a]indol-1-ones were investigated using UV-vis and fluorescence spectroscopy. Structures of all newly obtained compounds were elucidated by NMR, IR, HRMS or X-ray analyses.