I. Golinka “Research and development of methods and tools for microparticles separation from biological environments”

Thesis Defense

Author, Institution: Ievgeniia Golinka, Kaunas University of Technology,

Science area, field of science: Technological Sciences, Mechanical Engineering – 09T

Scientific Supervisor: Prof. Dr. Habil. Vytautas Ostaševičius (Kaunas University of Technology, Technological Sciences, Mechanical Engineering, 09T).

Dissertation Defence Board of Mechanical Engineering Science Field:
Prof. Dr. Habil. Arvydas Palevičius (Kaunas University of Technology, Technological Sciences, Mechanical Engineering, 09T) – chairperson
Dr. Rolanas Daukševičius (Kaunas University of Technology, Technological Sciences, Mechanical Engineering, 09T),
Prof. Dr. Evguenia Korobko (A.V. Luikov Heat and Mass Transfer Institute, Belarus, Technological Sciences, Mechanical Engineering, 09T),
Prof. Dr. Edgaras Stankevičius (Liethuanian University of Health Sciences, Biomedical Sciences, Medicine – 06B).

The doctoral dissertation is available at the libraries of Kaunas University of Technology (K. Donelaičio str. 20, Kaunas) and Aleksandras Stulginskis University (Studentų g. 11, Akademija, Kauno raj.).

Separation of micro-scale bioparticles is an important issue in the identification and analysis of industrial, biochemical and clinical applications. In order to achieve this goal, microfluidics have been actively adapted since they can accurately manipulate microparticles. Microfluidic microparticle separation techniques are divided into passive and active ones. In active techniques, magnetic or electric fields, optical interaction or acoustic waves are used for optical, magnetic or dialectical interaction of microparticles. Passive methods use distinctive physical properties of the particles, such as their size, density and, in particular, the deformability of cells. However, passive methods tend to suffer from lower selectivity than active methods. The intensification of life and the development of technologies increasingly require the treatment of a larger volume of bioparticles. There is obvious need for low-cost and energy-efficient microparticle separation/purification devices which would be easy to transport and quick to prepare for work in emergency situations (e.g., in a car accident). The research and development of such measures is covered in this work.

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