Author, Institution: Gabrielė Varvuolytė, Kaunas University of Technology
Science area, field of science: Natural Sciences, Chemistry, N003
Research supervisor: Prof. Dr. Hab. Algirdas Šačkus (Kaunas University of Technology, Natural Sciences, Chemistry, N003)
Research consultant: Assoc. Prof. Dr. Neringa Kleizienė (Kaunas University of Technology, Natural Sciences, Chemistry, N003)
Dissertation Defence Board of Chemistry Science Field:
Prof. Dr. Vytautas Getautis (Kaunas University of Technology, Natural Sciences, Chemistry, N003) – chairperson
Prof. Dr. Linas Labanauskas (State research institute Center for Physical Sciences and Technology, Natural Sciences, Chemistry, N003)
Dr. Gražvydas Lukinavičius (Max Planck Institute for Multidisciplinary Sciences, Germany, Natural Sciences, Chemistry, N003)
Prof. Dr. Hab. Vytautas Mickevičius (Kaunas University of Technology, Natural Sciences, Chemistry, N003)
Dr. Ingrida Tumosienė (Kaunas University of Technology, Natural Sciences, Chemistry, N003)
Dissertation defence meeting will be at Rectorate Hall of Kaunas University of Technology (K. Donelaičio 73-402, Kaunas)
The doctoral dissertation is available at the library of Kaunas University of Technology (Gedimino 50, Kaunas) and on the internet: G. Varvuolytė el. dissertation.pdf
Annotation: Heterocyclic compounds containing nitrogen, sulfur, and oxygen atoms, for instance, pyrazole, and benzo-fused heterocycles, such as indole, benzothiazole, or benzoxazole, are important scaffolds in medicinal chemistry for the development of new antiviral, antimicrobial, and anticancer agents. Certain compounds bearing pyrazole, 3H-indole, benzo[e]indole or benzothiazole moieties possess strong photocytotoxicity against melanoma or breast cancer cell lines. The most widely used treatments for these cancers involve adverse side effects, but photodynamic therapy, which relies on photosensitizers, shows promising results in the treatment of melanoma and breast cancer. However, aforementioned photosensitizers often suffer from disadvantages, such as complicated, lengthy synthesis and/or purification, poor photostability, and low selectivity towards cancer cells. Therefore, it is essential to continue the design and synthesis of new and improved photosensitizers for photodynamic therapy, especially styryl-heterocycles bearing pyrazole and/or benzoheterocycle moieties. In this dissertation, a series of pyrazole, indole, benzazole styryl derivatives are described, and their properties were investigated. It was determined that pyrazole-indole hybrids and benzo[e]indole derivatives show strong photocytotoxicity against melanoma and breast cancer cells.
June 13 d. 13:00
Rectorate Hall at Kaunas University of Technology (K. Donelaičio 73-402, Kaunas)
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