Author, Institution: Benas Balandis, Kaunas University of Technology
Science area, field of science: Natural Sciences, Chemistry, N003
Scientific Supervisor: Prof. Dr. Hab. Vytautas Mickevičius (Kaunas University of Technology, Natural Sciences, Chemistry, N003)
Dissertation Defense Board of Chemistry Science Field:
Prof. Dr. Vytautas Getautis (Kaunas University of Technology, Natural Sciences, Chemistry, N003) – chairperson
Senior Researcher Dr. Marytė Daškevičienė (Kaunas University of Technology, Natural Sciences, Chemistry, N003)
Prof. Dr. Vytas Martynaitis (Kaunas University of Technology, Natural Sciences, Chemistry, N003)
Assoc. Prof. Dr. Jolanta Rousseau (Artois University, France, Natural Sciences, Chemistry, N003)
Prof. Dr. Hab. Sigitas Tumkevičius (Vilnius University, Natural Sciences, Chemistry, N003)
Dissertation defense meeting will be at Rectorate Hall of Kaunas University of Technology (K. Donelaičio 73-402, Kaunas)
The doctoral dissertation is available at the library of Kaunas University of Technology (Gedimino 50, Kaunas)
Annotation: The current focus of medicinal chemistry is on exploring the mechanisms of disease origin and progression to identify specific targets or biological systems susceptible to intervention by synthetic agents. Benzenesulfonamide derivatives are pivotal in this endeavor, especially due to their potential as inhibitors of human carbonic anhydrases in anticancer drug development. This dissertation aimed to synthesize new benzenesulfonamide derivatives incorporating azole fragments, utilizing straightforward and efficient synthesis methods. The molecular structures of these derivatives were designed based on “one-tailed” and “two-tailed” approach for carbonic anhydrase inhibitors. The newly synthesized compounds were evaluated against human carbonic anhydrase isoforms. To enhance the interaction with the target protein and improve selectivity, azole moieties were incorporated into these structures. Additionally, the cytotoxic activity of selected compounds was assessed using both 2D and 3D cancer cell models. Furthermore, to explore their antibacterial potential, these azole derivatives were tested against the drug-resistant Mycobacterium abscessus complex.
June 14 d. 10:00
Rectorate Hall at Kaunas University of Technology (K. Donelaičio 73-402, Kaunas)
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