Author, Institution: Aistė Pupiūtė, Kaunas University of Technology
Science area, field of science: Natural Sciences, Chemistry, N003
Research supervisor: Chief Researcher Dr. Edvinas Krugly (Kaunas University of Technology, Natural Sciences, Chemistry, N003)
Research consultant: Assoc. Prof. Dr. Odeta Baniukaitienė (Kaunas University of Technology, Natural Sciences, Chemistry, N003)
Dissertation Defence Board of Chemistry Science Field:
Prof. Dr. Vytautas Getautis (Kaunas University of Technology, Natural Sciences, Chemistry, N003) – chairperson
Prof. Dr. Eglė Arbačiauskienė (Kaunas University of Technology, Natural Sciences, Chemistry, N003)
Prof. Dr. Saulius Grigalevičius (Kaunas University of Technology, Natural Sciences, Chemistry, N003)
Assoc. Prof. Dr. Jolanta Rousseau (Artois University, France, Technological Sciences, Chemical Engineering, T005)
Senior Researcher Dr. Ilona Uzielienė (State Research Institute Centre for Innovative Medicine, Natural Sciences, Biology, N010)
Dissertation defence meeting will be at Rectorate Hall of Kaunas University of Technology (K. Donelaičio 73-402, Kaunas)
The doctoral dissertation is available at the library of Kaunas University of Technology (Gedimino 50, Kaunas) and on the internet: A. Pupiūtė el. dissertation.pdf
© A. Pupiūtė, 2026 “The text of the thesis may not be copied, distributed, published, made public, including by making it publicly available on computer networks (Internet), reproduced in any form or by any means, including, but not limited to, electronic, mechanical or other means. Pursuant to Article 25(1) of the Law on Copyright and Related Rights of the Republic of Lithuania, a person with a disability who has difficulties in reading a document of a thesis published on the Internet, and insofar as this is justified by a particular disability, shall request that the document be made available in an alternative form by e-mail to doktorantura@ktu.lt.”
Annotation: In recent years, increasing attention has been focused on the development of advanced three-dimensional (3D) in vitro models capable of reproducing the structural and functional characteristics of human tissues. Conventional two-dimensional cell culture models do not adequately represent the native tissue microenvironment, highlighting the need for alternative approaches that more closely mimic physiological conditions. One promising strategy involves the development of fibrous polymeric scaffolds. These scaffolds enable control over pore and fiber dimensions, mechanical and surface properties, and cell distribution within 3D structures. However, reproducing complex tissue architectures by integrating distinct morphological and biochemical characteristics within a single system remains a significant scientific challenge. Addressing this challenge requires further advances in fibrous scaffold fabrication techniques and surface modification methods, as well as effective strategies for integrating functional hydrogels into scaffold structures. Such complex scaffolds can be used for advanced in vitro modeling of tumor, cartilage, and osteochondral tissues. The aim of this dissertation is to develop fibrous polymeric scaffolds with functional morphologies and demonstrate their applicability as complex 3D in vitro tissue models.