Author, Institution: Aušra Adomėnienė, Kaunas University of Technology
Science area, field of science: Natural Sciences, Chemistry, N003
Scientific Supervisor: Prof. Dr. Petras Rimantas Venskutonis (Kaunas University of Technology, Natural Sciences, Chemistry, N003)
Dissertation Defence Board of Chemistry Science Field:
Prof. Dr. Hab. Vytautas Mickevičius (Kaunas University of Technology, Natural Sciences, Chemistry, N003) – chairperson
Prof. Dr. Vytas Martynaitis (Kaunas University of Technology, Natural Sciences, Chemistry, N003)
Assoc. Prof. Dr. Milda Pukalskienė (Kaunas University of Technology, Technological Sciences, Chemical Engineering, T005)
Prof. Dr. Dalija Seglina (Latvia University of Life Sciences and Technologies, Institute of Horticulture, Latvia, Natural Sciences, Chemistry, N 003)
Assoc. Prof. Dr. Mantas Stankevičius (Vytautas Magnus University, Natural Sciences, Chemistry, N003)
Dissertation defence meeting will be at M7 Hall at The Campus Library of Kaunas University of Technology (Studentų 48–M7, Kaunas)
The doctoral dissertation is available at the library of Kaunas University of Technology (K. Donelaičio g. 20, Kaunas)
Annotation: The importance of controlling the activity of many enzymes has long been proven in medical science. Inhibition of certain hydrolase enzymes is recognized to be important in modulating physiological functions in the human body in cases of carbohydrate metabolism disorder, dementia, high blood pressure and some other health problems. It is also acknowledged that the effective use of phytochemicals in medicinal and other plants with inhibitory effects can significantly contribute to the prevention, risk reduction, and complex therapy of these negative physiological functions. It is also acknowledged that the effective use of phytochemicals in medicinal and other plants with inhibitory effects can significantly contribute to the prevention and complex therapy of these negative physiological functions. Studies conducted on the phytochemical composition and biological effects of plant raw materials can be used to enrich the assortment of medicinal plant raw materials. In this doctoral thesis, investigates phytochemical composition of D. caucasica, D. nipponica and A. glycyphyllos extracts and their ability to inhibit of physiologically important enzymes belonging to family of hydrolases. By applying biological methods, evaluated the effect of D. caucasica, D. nipponica and A. glycyphyllos extracts on hydrolase enzymes activities and theoretically formulated assumption that extracts contain natural compounds capable of binding with enzymes exhibiting hydrolase activity and thus reduce their activity.
This thesis provides insights, that the different anatomical parts of the plants D. caucasica, D. nipponica and A. glycyphyllos selected for the research may contain valuable phytochemical compounds that are little researched, which may be characterised by diverse bioactivity, including targeted effects on the activity of physiologically important enzymes – α-amylase, α‑glucosidase, angiotensin-converting enzyme and acetylcholinesterase.
June 22 d. 10:00
M7 Hall at The Campus Library of Kaunas University of Technology (Studentų 48–M7, Kaunas)
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